Geddes JR, Burgess S, Hawton K, Jamison K, Goodwin GM. After almost 70 years of medical research, lithium salts have been shown effective for the protection against mania and depression, especially in the acute and long-term management of bipolar disorder 2 2. The treatment of manic psychoses by the administration of lithium salts. Schou M, Juel-Nielsen N, Stromgren E, Voldby H. Lithium represents an important therapeutic option in mood disorders, since its first clinical study by Mogens Schou in 1954 1 1. LГtio transtornos de humor seguranГ§a tolerГўncia Em geral, o lГtio Г© ainda uma alternativa segura para o tratamento dos transtornos de humor. No entanto, tratamentos de mГ©dio a longo prazo com lГtio podem ter efeitos sobre ГіrgГЈos-alvo que podem ser prevenidos por acompanhamento periГіdico. : O tratamento de curto prazo com lГtio estГЎ associado com efeitos colaterais leves. Os medicamentos anti-inflamatГіrios nГЈo esteroides, diurГ©ticos, inibidores da enzima de conversГЈo da angiotensina e alprazolam podem aumentar o lГtio sГ©rico e o consequente risco de intoxicaГ§ГЈo. A evidГЄncia de teratogenicidade associada com o uso de lГtio nГЈo estГЎ bem estabelecida. TambГ©m foi observada reduГ§ГЈo da taxa de filtraГ§ГЈo glomerular em pacientes utilizando lГtio, mas em menor grau. UsuГЎrios de lГtio mostraram uma alta prevalГЄncia de hipotireoidismo, hiperparatireoidismo e diminuiГ§ГЈo da capacidade de concentraГ§ГЈo urinГЎria. : Os efeitos colaterais mais comuns nos pacientes em tratamento com lГtio foram sede, micГ§ГЈo frequente, boca seca, ganho de peso, fadiga e queixas cognitivas. Esta pesquisa inicial teve como objetivo selecionar ensaios clГnicos, estudos prospectivos e estudos controlados com tratamento com lГtio para transtornos de humor, relatando efeitos adversos (n = 36). : Uma busca informatizada para estudos com humanos escritos em inglГЄs foi feita no MEDLINE, usando as palavras-chave вЂњlГtioвЂќ e вЂњtranstornos de humorвЂќ, a partir de julho de 1993 a julho de 2013 (n = 416). Este estudo abrange uma ampla revisГЈo crГtica sobre a seguranГ§a e a tolerabilidade do lГtio para transtornos do humor. : O lГtio Г© um tratamento de primeira linha para o transtorno bipolar, em todas as fases, e tambГ©m Г© indicado como terapia adjunta para a depressГЈo unipolar e prevenГ§ГЈo do suicГdio. Lithium mood disorders safety tolerability Overall, lithium is still a safe option for the treatment of mood disorders. Medium and long-term lithium treatment, however, might have effects on target organs which may be prevented by periodical monitoring. : Short-term lithium treatment is associated with mild side effects. Anti-inflammatory non-steroidal drugs, thiazide diuretics, angiotensin-converting enzyme inhibitors, and alprazolam may increase serum lithium and the consequent risk for intoxication.

The evidence of teratogenicity associated with lithium use is not well established. Reduction of glomerular filtration rate in patients using lithium was also observed, but in a lesser extent. Lithium users showed a high prevalence of hypothyroidism, hyperparathyroidism, and decrease in urinary concentration ability. : The most common general side effects in patients on lithium treatment were thirst, frequent urination, dry mouth, weight gain, fatigue and cognitive complaints. This initial search aimed to select clinical trials, prospective data, and controlled design studies of lithium treatment for mood disorders reporting adverse effects (n = 36). : A computerized search for English written human studies was made in MEDLINE, using the keywords вЂњlithiumвЂќ and вЂњmood disordersвЂќ, starting from July 1993 through July 2013 (n = 416). This study encompasses a broad critical review on the safety and tolerability of lithium for mood disorders. : Lithium is a first-line treatment for bipolar disorder in all phases, also indicated as add-on drug for unipolar depression and suicide prevention.

Ace combat 7 pc completo